Clinical Research at SightMD

One of the most exciting aspects of medicine is continuous innovation, scientific exploration, and research into how we can provide enhanced care for our patients. The field of ophthalmology has been on the forefront and recipient of revolutionizing technology, novel medications, premium devices, and innovative surgical techniques. Individually or combined, these advancements have provided patients with better vision and improved treatment options.

At SightMD we are continuously coupling efforts with top-tiered patient-centric industry-leading companies to bring the newest techniques, technologies, and medications to our patients through our Department of Clinical Research. Lead by Dr. Alanna Nattis, she has designed, developed, and exclusively accessed investigational treatment studies for wide-ranging ophthalmic conditions such as severe dry eye, glaucoma, refractive and cataract surgery, and retinal pathologies. Having direct access to FDA clinical trials uniquely provides SightMD with state-of-the-art care for our current and future patients.

We are currently recruiting for several active clinical trials. Please contact us for more information!

Below is a list of active and soon-to-be enrolling trials at SightMD.

 

Ongoing/Currently Enrolling Research Studies

Open Angle Glaucoma and Ocular Hypertension:

Evaluation of medication-releasing intraocular implant to treat open angle glaucoma and ocular hypertension.

Prospective, Randomized Phase 3 Study Comparing Two Models of a Travoprost Intraocular Implant to Timolol Maleate Ophthalmic Solution, USP 0.5%

    • Principal Investigator (PI): Alanna Nattis, DO
    • Sub-Investigators (Sub-I’s): Richard Nattis MD, Raju Sarwal MD
    • Research Coordinator: Kathy Lemier, Sub-coordinator Mary Iaconis
    • Current patient enrollment: 18
    • Stage of Recruitment: Closed
    • Trial type: Phase 3 FDA

Post-Corneal-Crosslinking Inflammation and Pain:

Evaluation of anti-inflammatory (dexamethasone) punctal insert following corneal crosslinking to control inflammation and pain in comparison to topical steroid eye drops.

The LINK Study: Intracanalicular Dexamethasone Insert for Post-Corneal-Crosslinking Inflammation and Pain

  • PI: Alanna Nattis, DO
  • Sub-I: Eric Rosenberg, DO
  • Research Coordinator: Kathy Lemier
  • Current patient enrollment: 16
  • Stage of Recruitment: Open
  • Trial type: IIT


Neurotrophic Keratitis with Oxervate:

In-depth evaluation using high-resolution corneal imaging during and after treatment for patients with neurotrophic keratitis treated with Recombinant Human Nerve Growth Factor (Oxervate)

Using OCT to measure regeneration of the cornea during/after treatment of neurotrophic keratitis with Oxervate

  • PI: Brad Kligman MD
  • Research Coordinator: Monique Murray
  • Current patient enrollment: 3
  • Stage of Recruitment: Open
  • Trial type: IIT


ARTISAN Aphakia Lens:

Evaluation of visual outcomes following implantation of specialized intraocular lens in patients without natural crystalline lens (aphakia)

Clinical Investigation of the ARTISAN Aphakia Lens in Adults

  • PI: Alexander Hatsis MD
  • Sub-I: Alanna Nattis DO
  • Research Coordinator: Joann Hatsis RN
  • Current patient enrollment: 6
  • Stage of Recruitment: Open
  • Trial type: Phase 3 FDA


The ENHANCE Study (dry eye signs and symptoms following cataract surgery):

Evaluation of dry eye signs and symptoms following cataract surgery in patients receiving a dexamethasone intracanalicular insert vs. topical steroid

Evaluation of Vision Recovery and Comfort Index in Patients with Borderline/Mild Dry Eyes Undergoing Femtosecond Laser Assisted Cataract Surgery with Premium Intraocular Lens

  • PI: John Passarelli MD
  • Research Coordinator: Marshell Singleton RN
  • Current patient enrollment: 2
  • Stage of Recruitment: Open
  • Trial type: IIT


Vivity Extended Depth of Focus Intraocular Lens Study:

Evaluation of new extended vision (“extended depth of focus”) intraocular lens implant on visual success and quality of life following implantation during routine cataract surgery

Impact of a Novel Extended Depth of Focus Intraocular Lens on Visual and Lifestyle Enhancement (Vivity)

  • PI: Alanna Nattis DO
  • Sub-I: Eric Rosenberg DO, Richard Nattis MD, John Passarelli MD, Jordan Garelick MD, Craig Richter MD
  • Research Coordinator: Kathy Lemier
  • Current patient enrollment: 23
  • Stage of Recruitment: Open
  • Trial type: IIT


PanOptix Trifocal Intraocular Lens Study:

Evaluation of patient pre-and-perioperative factors on visual improvement following trifocal intraocular lens implant during cataract surgery

Evaluation of Pre-and Perioperative Variables on Visual Outcome and Patient Satisfaction with Trifocal Intraocular Lens Implantation – PanOptix

  • PI: Alanna Nattis, DO
  • Sub-I: Richard Nattis MD, John Passarelli MD, Jeffrey Martin MD, Jordan Garelick MD, Craig Richter MD
  • Research Coordinator: Kathy Lemier
  • Current patient enrollment: 40
  • Stage of Recruitment: Closed
  • Trial type: IIT


3D – Cataract Surgery Study
:

Evaluation of speed of visual recovery in cataract surgery patients undergoing surgery using a traditional operative microscope vs. a lower-light intensity, 3-D system

Prospective randomized evaluation and comparison of the effect of decreased illumination on visual recovery following cataract surgery

  • PI: Eric Rosenberg DO
  • Sub-I: Alanna Nattis DO
  • Research Coordinator: Mary Iaconis
  • Current patient enrollment: 50
  • Stage of Recruitment: Open
  • Trial type: IIT


NY Cancer and Blood Specialists clinical research partnership:

Eye exams provided to patients undergoing investigational research for novel chemotherapeutics/therapeutic regimens across the greater NYC area and Long Island

  • PI: several physicians across SightMD locations
  • Stage of Recruitment: Open


Soon-to-be Enrolling Studies

The Olympia Study:

Evaluation of the ability of a medication delivered via nasal spray to improve and treat earlier stage neurotrophic keratopathy

A phase 2, Multicenter, Randomized Controlled, Double-Masked Clinical Trial to Evaluate the Efficacy and Safety of OC-01 (Varenicline) Nasal Spray in subjects with Neurotrophic Keratopathy

  • PI: Eric Rosenberg DO
  • Sub-I: Alanna Nattis DO
  • Research Coordinator: Kathy Lemier
  • Trial type: Phase 2 FDA 


Telesto Study:

Evaluation of patient characteristics with signs and symptoms of dry eye and positive correlation with presence of Demodex mites

Correlation of Collarettes and Demodex with ocular surface signs and symptoms

  • PI: Alanna Nattis DO
  • Sub-I: Eric Rosenberg DO
  • Research Coordinator: Kathy Lemier
  • Trial type: IIT
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